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pentobarbital will lessen the extent or result of alfuzosin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unknown.pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can minimize panobinostat ranges by ~70% and cause treatmen